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Orthomolecular Methyl B Complex–60 capsules

Hans N

Mitochondria Nutrition PQQ

Awesome service! Thanks!!
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Mike K

Mitochondria Nutrition PQQ

Fantastically 😀 Quick delivery
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Elaine W

Mitochondria Nutrition PQQ

Great service and quick turn around!
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Mike K

MELATONIN 60 MG 60 CAPS

The 60mg melatonin are perfect. The prompt delivery is most appreciated!.
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Kevan L

ProBalance Transdermal Cream 2oz

Very happy, thank you.
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Sherri T

THYROID PX

I feel this product helps keep my thyroid working along with my NP Thyroid RX.
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Cheryl A

Ashwagandha 350 mg 180 Caps

Got my order quickly. This Ashwagandha helps me to relax and sleep and not have panic attacks like I used to. Thanks
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Lisa J

Liposomal Glutathione Liquid 4 oz

My order was filled in a timely manner and the product is good in dealing with inflammation.
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Patricia C

Sodium Potassium Bicarbonate 120grams

I’m happy to be restocked with my old standby! Service was great. Order was processed and shipped in a timely manner. Thank you.
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Rebecca L

MELATONIN 60 MG 60 CAPS

Outstanding in all ways!
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Angel W

Ther-Biotic Complete Powder 100+billion CFU 60 grams (Refrigerated)

Arrived quickly. Thank you!
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CHARLES W III D

Mitochondria Nutrition PQQ

You did great! Order came quickly and safely packaged. Thank you!
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June H

LB CORE PROTOCOL

The LB Protocol is an excellent product. I’ve been using it for years.
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Elizabeth S

Liposomal Glutathione Liquid 4 oz

The order was filled in a timely basis and arrived sooner than I expected
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Kathie K

Vitamin D3 5000 i.u. 250 capsules

Product and delivery good
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Dennis D

REJUVENESCENCE – NUTRIENT RICH REVITALIZING FACE CREAM

After opening and trying the Revitalizing Cream, I immediately ordered a second bottle. I love this stuff!!
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Jan M

REJUVENESCENCE – NUTRIENT RICH REVITALIZING FACE CREAM

Rejuvenescence cream has helped lessen the itch and flaky condition of my skin especially my legs. Although I find that it needs to be reapplied about 3hrs later. I like the way it absorbs quickly and leaves no sticky or greasy residue. There is no scent which is a blessing. I will be purchasing this product in the future.
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Debra B

OsteoThera w Ipraflavones

All went well with the order and delivery. Items were exactly as I expected. Thanks for the extra supplement.
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Nancy G

REJUVENESCENCE – NUTRIENT RICH REVITALIZING FACE CREAM

Great response time!
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Cathy B

Liposomal Glutathione Liquid 4 oz

Great service and always have my favorite items in stock for easy ordering and delivery! Thank you!
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Sandra C

Adrenal Px Balance 75 CAPSULES

Best price online!
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Sarah G

GTA-FORTE

I’m very happy with my order. Thank you so much!
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Michelle B

MELATONIN STRONG 60 MG – 60 CAPS

Well done. Great product not offered anywhere else. Thank you
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Debbie P

CISTANCHE HIGH POTENCY 500 MG

Bob B

Mitochondria Nutrition PQQ

Great customer service!!!
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Mike K

Mitochondria Nutrition PQQ

Great product. The best daily vitamin I’ve ever taken.
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Nancy F

Mitochondria Nutrition PQQ

I received my order in record time. Amazon could not have beaten the price and timing. Thank you for excellent customer service.
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Linda S

Mitochondria Nutrition PQQ

Great job as always
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IRIS H

READISORB GO – LIPOSOMAL GLUTATHIONE POWDER PACKS – 30

Order was correct, and you got it to me quickly. Thank you!
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Joyce P

M4SL

Good service, thank you!
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Alice L

REVERSE T3

SKU 84482
$30.00
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REVERSE T3

Product Details
Clover Product ID: BX1M31WRMYXYW
UPC: 84482
Brand: no

REVERSE T3


Reverse triiodothyronine (rT3) is an isomer of triiodothyronine (T3) with no demonstrated biological activity.1,2 The majority of rT3 is produced through peripheral enzymatic monodeiodination of T4 at the 5 position of the inner ring of the iodothyronine nucleus of thyroxine (T4). A lesser amount of rT3 is secreted directly by the thyroid gland. Reverse T3 is biologically inactive and does not stimulate thyroid hormone receptors.

Multiple changes in serum thyroid hormone levels are commonly observed secondary to acute (eg, septic shock, myocardial infarction) or chronic (eg, cancer, advanced acquired immunodeficiency syndrome) systemic nonthyroidal illnesses.1-3 The hallmark features of this "nonthyroidal illness syndrome" are a low serum T3 level accompanied by an increase in serum rT3 level. Diminished serum T3 levels (the most biologically-active thyroid hormone) are thought to reflect altered thyroid homeostasis as a mechanism of adapting to severe illness.1 "Low T3 syndrome" affects the majority of critically ill patients and many outpatients suffering less acute illness.1,2 Thyroid-stimulating hormone (TSH), thyroxine (T4), free T4 (FT4), and free T4 index (FTI) can also be affected to variable degrees depending on the severity and duration of the illness.1-3 This constellation of abnormal thyroid hormone levels has historically been referred to as the euthyroid sick syndrome (ESS), because these patients are considered to be clinically euthyroid and typically have no hypothalamic, pituitary, or thyroid gland dysfunction, and thyroid hormone levels generally normalize on resolution of the underlying illness.1,2

The conversion of T4 to rT3 is increased in ESS in large part because of increased 5'-deiodinase activity in the periphery.1,2 This is often referred to as the "thyroid hormone inactivating pathway" because it reduces the amount of T4 available for conversion to biologically active T3.1,2 Also, the conversion of rT3 to diiodothyronine (T2) is reduced in nonthyroidal illness because of inhibition of the 5'-monodeiodinase activity.1 A number of studies have revealed that the expression of these deiodinases is modified by illness in a highly organ-specific manner resulting in tissue-specific modifications to thyroid status.2

In acutely ill patients (after acute myocardial infarction or other patients in intensive care), an elevated rT3 level has been found to independently predict increased mortality.4-8 Significant changes in rT3 occur rapidly in acute illness with maximal changes 24 to 36 hours after the onset of symptoms.6,7 Reverse T3 increase also appears to correlate with the degree of myocardial function impairment in patients with heart failure.8

Reverse T3 is often increased in nonacutely ill elderly people.3,9,10 The Alsanut study, an epidemiological study conducted in the late 1980s, was designed to determine the prevalence of thyroid dysfunction in an independently living population of 440 elderly individuals.9 This study revealed a significant relationship between increased rT3 and shorter survival while taking into consideration other critical confounders such as age, gender, medical history, nutritional parameters, and energy intake. In this study, rT3 was the only thyroid hormone associated with shorter survival.9 van den Beld found that elderly persons with isolated increased rT3 had lower physical performance and that elevated rT3 may be associated with a poor global health status.10 Forestier found a strong association between rT3 and survival in a population of independently living elderly subjects regardless of other confounding factors.3

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